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KMID : 0043320070300111392
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Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1392 ~ p.1397
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Antioxidant and Antiatherogenic Activity of cis-Hinokiresinol from Trapa pseudoincisa
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Song Myoung-Chong
Yang Hye-Joung
Bang Myun-Ho
Kim Dae-Keun
Jeong Tae-Sook
Kim Jong-Pyung
Baek Nam-In
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Abstract
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cis-Hinokiresinol, also known as (+)-nyasol, was isolated for the first time from an aquatic herbaceous plant, Trapa pseudoincisa NAKAI, via silica gel and octadecyl silica gel column chromatographies. The chemical structure was determined via analyses of the spectroscopic data, including NMR, MS and IR. cis-Hinokiresinol was also found to exhibit antioxidant and antiatherogenic activities. The IC50 values for the scavenging activities of cis-hinokiresinol on ABTS cation and superoxide anion radicals were 45.6 and 40.5 킡, respectively. The IC50 values for the inhibitory effects on Lp-PLA2, hACAT1, hACAT2 and LDL-oxidation were 284.7, 280.6, 398.9 and 5.6 킡, respectively
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KEYWORD
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Trapa pseudoincisa, cis-Hinokiresinol, ABTS, Superoxide, Lp-PLA2, hACAT, LDLoxidation
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